U-47700 (Pink) Drug: Effects, Hazards & Warnings - Drugs.com (2024)

Common or street names: Pink, Pinky, U4

What is U-47700 or Pink?

U-47700, also known as “Pink”, "Pinky", or “U4” on the streets, is a potent, synthetic opioid medication developed as a dangerous designer drug. Even small doses can be very toxic or even deadly. Reports have surfaced of multiple deaths due to street use of U-47700 or "Pink". Importation into the U.S. is primarily from illegal chemical labs in China.

How is "Pink" sold?

U-47700 has been seized by law officials on the street in powder form and as tablets. Typically it appears as a white or light pinkish, chalky powder.

It may be sold in glassine bags stamped with logos imitating heroin, in envelopes and inside knotted corners of plastic bags. Labels on the products may state “not for human consumption” or “for research purposes only”, probably in an effort to avoid legal detection. Some "Pink" products have been sold to mimic bags of heroin or prescription opioid tablets.

In Ohio, authorities seized 500 pills resembling a manufacturer’s oxycodone immediate-release tablets, but they were confirmed by chemical analysis to contain “Pink”.

U-47700 has also been identified and sold on the Internet misleadingly as a “research chemical” at roughly $30 per gram.

How dangerous is Pink (U-47700)?

Fatalities due to Pink (U-47700) in the United States join the growing incidence of drug overdose or deaths due to prescription opioids and synthetic designer drugs like “spice” and “bath salts.” The public using these street or Internet products can never know exactly what is in them, how much, or the degree of toxicity with use.

The Drug Enforcement Agency (DEA) reported at least 46 deaths linked to use of U-47700 that occurred in 2015 and 2016. Fatalities have been reported in Arizona, New York, New Hampshire, Ohio, Texas, and Wisconsin, North Carolina, with multiple reports from state and local forensics laboratories. According to DEA, no other reports of use in the U.S. were found prior to 2015.

Those who abuse U-47700 may be at risk of addiction and substance abuse disorder, overdose and death, similar to abuse of other narcotic substances such as heroin, prescription pain opioids, and designer opioids. This drug may be found in combination, knowingly or unknowingly, with other drugs of abuse bought on the streets such as heroin or fentanyl. It has also been confiscated as a separate product.

A toxicology case report was published in the Annals of Emergency Medicine that detailed events in which fentanyl and U-47700 were being sold misleadingly as the prescription opioid pain medication Norco (acetaminophen and hydrocodone) on the streets of Northern and Central California. In one patient who presented to the emergency room, naloxone (Narcan) was administered which reversed respiratory depression and pinpoint pupils. After additional chemical analysis, it was found the “Norco” contained hydrocodone, fentanyl, and U-47700.

Where does Pink (U-47700) come from?

These illicit substances appear to originate from overseas, mainly China, and the identity, purity, and quantity of substances in any one product purchased off the street may be unknown. A user may be told the product contains one substance, while in reality it could contain any dangerous chemical.

Pharmacology of Pink (U-47700)

U-47700 (“Pink”) is a novel synthetic opioid agonist with selective action at the mu-opioid receptor.

The chemical designation is 3,4-dichloro-N-[2-dimethylamino) cyclohenyl]-N-methylbenzamide.

It was originally developed by chemists at Upjohn Pharmaceuticals in the 1970’s as a potent pain reliever for use in surgery, cancer, or painful injuries. Although it was never commercially made available, the patent and chemical details remained available.

U-47700 has a similar chemical profile as morphine and other mu-opioid receptor agonists; however, it has been reported by the National Institute of Drug Abuse (NIDA) that Pink is “far more potent than morphine” -- possibly seven to eight times more potent.

The strength of the product can never be assured, and may be much stronger, as it is a designer drug made in illegal labs.

Animal studies have shown that the analgesic activity of U-47700 was reduced by naltrexone, an opioid receptor antagonist.

DEA schedule of Pink (U-47700)

In 2018, the DEA issued a Final Order to place U-47700, as well as its related isomers, esters, ethers, and salts into Schedule I of the Controlled Substances Act due to an imminent hazard to public safety and health.

Substances in schedule I have a high potential for abuse, no currently accepted medical use, and a lack of accepted safety for use under medical supervision. DEA’s Final Order of scheduling into 21 CFR 1308.11(b) is available in the Federal Register with details on threats to public safety.

In 2016, U-47700 had previously been placed in Schedule I temporarily to determine its final status. Temporary emergency scheduling of dangerous illicit drugs is one tool the DEA uses to help restrict potentially fatal and new street drugs. Scheduling usually last at least 24 months, with a possible 12-month extension if the DEA needs more time to determine if the chemical should remain permanently in schedule I. According to the Federal Register at that time, there were no current investigational or approved new drug applications for U-47700 which might hinder its placement in Schedule I.

Prior to the DEA’s emergency scheduling, several states had already outlawed the drug under emergency orders, including Florida, Ohio, Wyoming and Georgia.

Pink (U-47700) side effects and toxicity

U-47700 or “Pink” is abused for its opioid and narcotic-like effects, and is swallowed, snorted or injected. It is one of many synthetic designer drugs. Pink effects as reported by users are similar to the effects of opioids, which might include:

-euphoria, feeling "high", and other psychoactive effect

-sedation, relaxation, numbness

-potent analgesia

-severe, possibly fatal respiratory depression

-pinpoint pupils

-constipation

-itching

-drug tolerance, dependence, addiction

-seizures

-psychosis

-fatal overdose

-potent analgesia

One published review noted that patients that died after an overdose with U-47700 typically presented to the hospital with pulmonary edema (excess fluid in the lungs).

Does Pink show up on drug tests?

Currently, U-47700 is not included in standard workplace drug screens in the U.S.; however, forensics or medical laboratory testing may request to identify U-47700 through analytical techniques such as gas chromatography and mass spectrometry (GC-MS).

In-hospital immunoassays do not normally identify U-47700 and special techniques such as GC-MS must be used.

Learn More: Drug Testing FAQs

Bottom line on Pink

U-47700, known on the streets as Pink or U4, is a dangerous designer drug exported from illegal labs in China to the U.S. It has effects like a strong opioid analgesic, and have been reported to be 7 to 8 times more potent than morphine. U-47700 is now illegal in all forms, and the DEA has placed the substance into Schedule I of the Controlled Substances Act, due to an imminent hazard to public safety and health.

Authorities in many U.S. cities have reported that Pink is sold on the streets or over the Internet, often promoted as a prescription opioid like Norco or as heroin. Many of these products, when confiscated and analyzed, have contained this potent designer drug, as well as fentanyl.

Clusters of overdoses and deaths in U.S. cities were reported in 2015-2017 with Pink; some in children. According to one case report, the use of naloxone (Narcan) in an emergency setting reversed the effects of U-47700. Emergency physicians should contact their local poison control center, medical toxicologist or public health department in cases where there is a reasonable suspicion of ingestion of designer drugs to help protect the surrounding community. Special lab analysis may be needed to identify drugs like Pink.

The public should be aware that drugs obtained on the street, even though they look like an authentic prescription medication, may be fake and deadly. Don't take any prescription drug -- legal or otherwise -- unless it is written specifically for you by a doctor and is dispensed from a reliable pharmacy.

U-47700 (Pink) Drug: Effects, Hazards & Warnings - Drugs.com (2024)

FAQs

How long does the pink pill last? ›

Immediate-Release Formulation: The pink K56 pill is an immediate-release form of oxycodone. It starts to reach peak effectiveness within 15 to 30 minutes after ingestion and remains effective for approximately three to six hours. It is typically prescribed to be taken every four to six hours as needed for pain​.

What drug is a pink pill? ›

Pink Oxycodone is a version of the popular opioid pain medication. Pink Oxycodone is an immediate-release form of oxycodone hydrochloride 10 mg. This drug is a Schedule II controlled substance. This oxycodone pill can be colored white, green, or blue – not just pink.

What are the U series opioids? ›

IMF, fentanyl analogs, heroin, and illicitly manufactured U-series drugs. U-series drugs are novel nonfentanyl-related synthetic opioids with no authorized medical uses. U-series drug deaths include those involving U-47700 and its analogs U-48800 and U-49900.

What is the little pink pain killer? ›

Oxycodone Hydrochloride Tablets, USP: 5 mg: White round biconvex tablets debossed "K" on left and "18" on right of the bisect on one side and plain on the other side. 10 mg: Pink round biconvex tablets debossed "K" on left and "56" on right of the bisect on one side and plain on the other side.

What does the pink pill do to your body? ›

It works by changing levels of dopamine, norepinephrine and serotonin, chemicals in the brain that send signals to other parts of the body. Dopamine, norepinephrine and serotonin are all thought to play a critical role in feelings of sexual desire and arousal.

What are the risks of taking the pink pill? ›

There are also reports of fainting and drowsiness, which has been shown to lead to a higher risk of accidents, and there are concerns about the potential increases risk for these side effects when the drug is combined with alcohol.

What schedule is U 47700? ›

Structure of U-47700

The Drug Enforcement Administration (DEA) made U-47700 a schedule I substance in November 2016.

What is the FDA pink pill? ›

Once-daily, non-hormonal Addyi is the only FDA-approved pill proven effective for Hypoactive Sexual Desire Disorder (HSDD aka frustrating low libido) in certain premenopausal women.

Which is stronger, oxycodone or hydrocodone? ›

Is there a difference between hydrocodone and oxycodone? One key difference is that oxycodone is more potent than hydrocodone. This means that it takes less oxycodone to produce the same effects as hydrocodone. Oxycodone is also more likely to be abused than hydrocodone because it produces stronger effects.

What is the strongest painkiller? ›

Carfentanil: Carfentanil, a synthetic opioid, is a 100-fold stronger version of fentanyl. It has 5,000 times the potency of heroin and 10,000 times the potency of morphine. There has been an increase in the amount of carfentanil in narcotics, and this substance nearly invariably results in overdose and death.

What are the top 5 opioids? ›

They work by targeting opioid receptors in the brain to block the feeling of pain.
  • OxyContin (Oxycodone)
  • Vicodin, Norco and Lortab (Hydrocodone with Acetaminophen)
  • Percocet (Oxycodone with Acetaminophen)
  • Tramadol.

What are the 4 main opioids? ›

Common types are oxycodone (OxyContin), hydrocodone (Vicodin), morphine, and methadone.

Is oxycodone the same as percocet? ›

Percocet contains five milligrams of oxycodone, which is all released when the pill is taken. Percocet also contains acetaminophen (the drug in Tylenol), which can cause liver damage if you take a lot of it. Oxycodone-CR products contain only oxycodone. When taken as prescribed, the drug is released over several hours.

What is a pink pill with a 5 on it? ›

Pill with imprint 5 is Pink, Round and has been identified as Lisinopril 5 mg. It is supplied by Lupin Pharmaceuticals, Inc. Lisinopril is used in the treatment of Heart Attack; High Blood Pressure; Heart Failure and belongs to the drug class Angiotensin Converting Enzyme Inhibitors.

What is the M on a pink pain pill? ›

Pill with imprint M 10 is Pink, Round and has been identified as Oxycodone Hydrochloride 10 mg. It is supplied by SpecGx LLC. Oxycodone is used in the treatment of Chronic Pain; Back Pain; Pain and belongs to the drug class Opioids (narcotic analgesics). FDA has not classified the drug for risk during pregnancy.

How effective is the pink pill? ›

It turns out about 10% of women respond. So if you give this drug to 100 women, and you give placebo to 100 women, 34 out of 100 of women with placebo will get better, they'll have more interest in sex and they'll have more sexually satisfying sexual activity. If you give flibanserin, 46% will feel better.

How long does the pill stay in you? ›

The pill and minipill: The hormones from the pill or minipill will leave your system 48 hours after the last pill was taken. Expect your menstrual cycles and ovulation to return to your "normal" within three months after stopping the pill.

What is the pink pill that makes you happy? ›

Just when you think there's nothing available to help amp up your sex drive, think again. Disguised as a little pink pill, flibanserin (Addyi®) is used only to treat HSDD. But is this pink pill for you? If you're merely looking for something to put you in the mood, the answer is no.

Does the pink pill prevent pregnancy? ›

The light pink pills are “active,” which means they contain hormones that prevent pregnancy. Take them at the same time each day to get into the habit of taking your pill. Doing so is critical to ensuring the pill is working to prevent pregnancy. From Day 25 to 28 you should take one white pill each day.

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